UDC 547.792 – 116.03/.56/12/.4.057
Pruglo E.S., Parchenko V.V., Panasenko O.I., Knysh E.G.
ANTIDEPRESSANT ACTIVITY OF THE 5-(FURAN-2-YL, 2-METHYLFURAN-3YL)-4-((ARYL, HETARYL)YLIDEN)AMINO-1,2,4-TRIAZOLE-3-THIOLS DERIVATIVES
Zaporizhzhia State Medical University
Zaporizhzhia, Mayakovsky Avenue 26, 69035
The article is dedicated to the research of antidepressant activity of the heterocyclic derivatives of 1,2,4-triazole. Experiments were conducted on nonlinear white rats. The antidepressant activity was studied through the Porsolt forced swimming test. Fluoxetine (10 mg/kg) was chosen for a comparison as a drug with antidepressant activity. It appeared that the compounds being currently researched show the evident antidepressant activity. The acute antidepressant activity along with low toxicity make it reasonable to continue further profound preclinical studies of derivatives of the 1,2,4-triazole heterocyclic group.
Key words: antidepressant activity, 1,2,4-triazole, the forced swimming test